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Related Experiment Video

Updated: Jun 24, 2026

Multiplex Immunohistochemical Analysis of the Spatial Immune Cell Landscape of the Tumor Microenvironment

Multiplex Immunohistochemical Analysis of the Spatial Immune Cell Landscape of the Tumor Microenvironment

Published on: August 18, 2023

Visualizing immune system complexity.

Michael L Dustin¹

¹Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University, New York, NY 10016, USA. michael.dustin@med.nyu.edu

Science Signaling

|April 16, 2009

Summary

This summary is machine-generated.

The EMBO meeting explored visualizing immune system complexity using advanced imaging techniques and computational modeling. This approach integrated single-molecule analysis to whole-animal imaging for dissecting diseases like type 1 diabetes.

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Area of Science:

Immunology
Molecular Biology
Biophysics

Background:

The European Molecular Biology Organization (EMBO) meeting focused on visualizing the complexity of the immune system.
The scope ranged from single-molecule imaging to whole-animal imaging.

Framework:

Emphasis on computational modeling for data analysis and predictive experimental design.
Integration of diverse imaging technologies including total internal reflection fluorescence microscopy, fluorescence correlation spectroscopy, two-photon laser scanning microscopy, and magnetic resonance imaging.

Implementation:

Exploration of fundamental aspects of adaptive and innate immunity.
Utilized a type 1 diabetes model to demonstrate multi-scale dissection of a human disease.

Implications:

Advanced imaging and modeling provide a comprehensive approach to understanding immune system complexity.
Multi-scale analysis, from molecular interactions to cellular dynamics and diagnostics, is crucial for disease research.