Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Dysrhythmias III: Characteristics of Dysrhythmias

Dysrhythmias III: Characteristics of Dysrhythmias

Dysrhythmias, also known as arrhythmias, are irregular heart rhythms that result from abnormal electrical activity in the heart, affecting its ability to circulate blood efficiently. Tachyarrhythmias, a subset of dysrhythmias, are characterized by abnormally fast heart rates exceeding 100 beats per minute. Here are some types of tachyarrhythmias with their distinct ECG features:Sinus Tachycardia:Sinus tachycardia presents a regular heart rhythm with an increased rate of 101-180 beats per minute.

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...

Mechanism of Cardiac Arrhythmias

Mechanism of Cardiac Arrhythmias

Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.

Electrophysiology of Normal Cardiac Rhythm

Electrophysiology of Normal Cardiac Rhythm

The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase of...

Disturbances in Heart Rhythm

Disturbances in Heart Rhythm

Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...

Dysrhythmias I: Introduction

Dysrhythmias I: Introduction

Dysrhythmias refers to abnormalities in the heart's rhythm. They result from disruptions in the heart's electrical conduction system, which includes the sinoatrial(SA)node, atrioventricular(AV) node, the bundle of His, bundle branches, and Purkinje fibers.Definition and PathophysiologyDysrhythmias result from disorders of impulse formation, impulse conduction, or both. The heart contains specialized cells in the sinoatrial node, atrioventricular node, and the bundle of His and Purkinje fibers...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Electric bicycles-related orthopedic injury spectrum: retrospective analysis of 1,735 cases (2020-2025).

Journal of orthopaedic surgery and research·2026

Same author

Pressure induced structural transition and optoelectronic modification in inorganic metavanadate phosphor.

The Journal of chemical physics·2026

Same author

Si-Ni-San alleviates depression-like behavior via regulating the gut microbiota-tryptophan metabolism-AhR/NF-κB pathway axis.

Chinese medicine·2026

Same author

Anemia in children with congenital heart disease and its association with postoperative prognosis.

Italian journal of pediatrics·2026

Same author

Optimization and mechanistic research on perchlorate removal by granular activated carbon-supported nanoscale zero-valent iron.

Environmental research·2026

Same author

Liposomal Delivery of <i>Macleaya cordata</i> Extract Alleviates Bacterial Diarrhea Through Intestinal Barrier Restoration, Microbiota Remodeling, and Inhibition of Inflammatory Factor Release.

Pharmaceutics·2026

Search research articles

Related Experiment Video

Updated: Jun 24, 2026

A Model of Long-Term Ventricular Fibrillation in Isolated Rat Hearts

A Model of Long-Term Ventricular Fibrillation in Isolated Rat Hearts

Published on: February 17, 2023

Sevoflurane postconditioning converts persistent ventricular fibrillation into regular rhythm.

Fengjiang Zhang¹, Gang Chen, Congcong Chen

¹Department of Anesthesiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

European Journal of Anaesthesiology

|April 16, 2009

Summary

This summary is machine-generated.

Sevoflurane postconditioning effectively converted persistent ventricular fibrillation to a regular rhythm in isolated rat hearts. This anesthetic intervention shows promise as a novel antiarrhythmic therapy for reperfusion-related arrhythmias.

More Related Videos

Transesophageal Atrial Burst Pacing for Atrial Fibrillation Induction in Rats

Transesophageal Atrial Burst Pacing for Atrial Fibrillation Induction in Rats

Published on: February 14, 2022

Related Experiment Videos

Last Updated: Jun 24, 2026

A Model of Long-Term Ventricular Fibrillation in Isolated Rat Hearts

A Model of Long-Term Ventricular Fibrillation in Isolated Rat Hearts

Published on: February 17, 2023

Transesophageal Atrial Burst Pacing for Atrial Fibrillation Induction in Rats

Transesophageal Atrial Burst Pacing for Atrial Fibrillation Induction in Rats

Published on: February 14, 2022

Area of Science:

Cardiology
Anesthesiology
Pharmacology

Background:

Ischemic postconditioning can restore sinus rhythm from ventricular fibrillation.
The antiarrhythmic effects of anesthetic postconditioning remain largely undetermined.
Investigating sevoflurane's impact on reperfusion-induced ventricular fibrillation is crucial.

Purpose of the Study:

To evaluate the antiarrhythmic efficacy of sevoflurane postconditioning.
To determine if sevoflurane can convert persistent ventricular fibrillation to sinus rhythm.
To assess sevoflurane's effect on ventricular function and cellular injury during reperfusion.

Main Methods:

Isolated Langendorff-perfused rat hearts underwent global ischemia and reperfusion.
Hearts with persistent ventricular fibrillation were randomized into control or sevoflurane postconditioning groups.
Ventricular pressures, heart rate, coronary flow, and infarct size were measured.

Main Results:

All sevoflurane-treated hearts converted from ventricular fibrillation to regular rhythm.
Regular beating was sustained throughout reperfusion in the sevoflurane group.
Coronary flow increased in sevoflurane postconditioned hearts compared to controls.

Conclusions:

Sevoflurane postconditioning demonstrates a potent antiarrhythmic effect against persistent ventricular fibrillation.
Anesthetic postconditioning, specifically with sevoflurane, holds potential as an antiarrhythmic strategy.
This approach may offer a new therapeutic avenue for managing reperfusion arrhythmias.