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Related Experiment Video

Updated: Jun 24, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

Comorbidity between depression and cardiovascular disease.

A Halaris1

  • 1Department of Psychiatry, Loyola University Stritch School of Medicine, Maywood, IL 60153, USA. ahalaris@lumc.edu

International Angiology : a Journal of the International Union of Angiology
|April 16, 2009
PubMed
Summary

Depression significantly increases cardiovascular disease (CVD) risk and mortality. Treating depression, particularly with selective serotonin reuptake inhibitors (SSRIs), may reduce CVD morbidity and mortality by addressing underlying biological mechanisms.

Related Experiment Videos

Last Updated: Jun 24, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

Area of Science:

  • Cardiology
  • Psychiatry
  • Psychoneuroimmunology

Background:

  • Cardiovascular disease (CVD) is a leading cause of death globally.
  • Depression is a prevalent psychiatric disorder with significant comorbidity with CVD.
  • Individuals with depression exhibit a two-fold higher risk of developing CVD and poorer outcomes post-myocardial infarction.

Purpose of the Study:

  • To explore the complex mechanisms underlying the comorbidity of depression and CVD.
  • To identify potential biological links and therapeutic targets for managing comorbid depression and CVD.

Main Methods:

  • Review of epidemiological studies and pathophysiological research.
  • Examination of neuroendocrine, autonomic, inflammatory, and platelet function in depression.
  • Analysis of the role of serotonergic pathways in linking depression and CVD.

Main Results:

  • Depression is associated with sympathoadrenal activation, HPA axis dysregulation, and inflammation.
  • Platelet activation and hypercoagulability are observed in depression, potentially reversible with SSRIs.
  • Endothelial dysfunction may serve as a trait marker for depression.

Conclusions:

  • Shared pathophysiological mechanisms, including autonomic imbalance and inflammation, link depression and CVD.
  • Selective serotonin reuptake inhibitors (SSRIs) show promise in ameliorating depression and reducing cardiovascular risk.
  • Vigorous treatment of comorbid depression is crucial for improving cardiovascular outcomes.