Related Experiment Video
Updated: Jun 24, 2026

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
Published on: December 30, 2016
Fast multiecho balanced SSFP metabolite mapping of (1)H and hyperpolarized (13)C compounds
Jochen Leupold1, Sven Månsson, J Stefan Petersson
1Department of Diagnostic Radiology, Medical Physics, University Hospital Freiburg, Freiburg, Germany. jochen.leupold@uniklinik-freiburg.de
Object:
To investigate the feasibility of multiecho balanced steady-state free precession (bSSFP)-based fast chemical shift mapping hyperpolarized (13)C metabolites. The overall goal was to reduce total imaging time and to increase spatial resolution compared to common chemical shift imaging (CSI).
Materials And Methods:
A multiecho bSSFP sequence in combination with an iterative reconstruction algorithm was implemented. (1)H experiments were performed on phantoms and on a human volunteer in order to investigate the feasibility of the method on a system with metabolite maps that are known beforehand. (13)C experiments were performed in vivo on pigs, where CSI images were acquired also for comparison.
Results:
Chemical shift images of three and four distinct (1)H resonance frequencies as well as chemical shift images of up to five hyperpolarized (13)C metabolites were successfully obtained.
Conclusion:
Fast metabolite mapping based on multiecho balanced SSFP in combination with an iterative reconstruction approach could successfully separate several (1)H resonances and hyperpolarized (13)C metabolites.
More Related Videos
Related Concept Videos
¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)
¹³C NMR: ¹H–¹³C Decoupling
A broadband decoupling technique is used to simplify these complex, sometimes overlapping, signals. Broadband decoupling relies on a...
Double Resonance Techniques: Overview
Spin decoupling is usually achieved by...
2D NMR: Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC)
¹H NMR: Complex Splitting
Splitting diagrams or splitting tree diagrams are routinely used to depict such complex couplings. While drawing splitting diagrams, the splitting with the larger coupling constant is usually applied first.
Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)

