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Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents

Published on: August 22, 2025

The endocannabinoid system in neuropathological states.

José Martínez Orgado¹, Javier Fernández-Ruiz, Julián Romero

¹Laboratorio de Apoyo a la Investigacion, Fundacion Hospital Alcorcon-CIBERNED, Madrid, Spain. jromero@fhalcorcon.es

International Review of Psychiatry (Abingdon, England)

|April 16, 2009

Summary

The endocannabinoid system (ECS) modulates brain function and is altered in neurodegenerative diseases like Alzheimer's and Parkinson's. Cannabinoid compounds may offer therapeutic benefits for these conditions.

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Lipidomics and Transcriptomics in Neurological Diseases

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

Area of Science:

Neuroscience
Pharmacology

Background:

The endocannabinoid system (ECS) plays a crucial role in modulating central nervous system (CNS) functions, including synaptic transmission.
Alterations in ECS components, such as cannabinoid receptors (CB1R, CB2R) and endocannabinoids, are observed in neuropathological conditions.

Purpose of the Study:

To review changes in cannabinoid signaling in neurodegenerative diseases.
To explore the potential therapeutic applications of cannabinoids in Alzheimer's disease, Parkinson's disease, and ischemia.

Main Methods:

Review of scientific literature on the ECS in neurodegeneration.
Analysis of human and animal models of Alzheimer's disease, Parkinson's disease, and ischemia.
Examination of cannabinoid signaling pathway alterations.

Main Results:

Significant alterations in ECS activity, including changes in receptor expression and endocannabinoid levels, are associated with neurodegenerative diseases.
Cannabinoid signaling is implicated in the pathophysiology of Alzheimer's disease, Parkinson's disease, and ischemic stroke.

Conclusions:

The ECS is a relevant target for therapeutic interventions in neurodegenerative disorders.
Cannabinoid-based strategies show promise for alleviating symptoms and potentially slowing disease progression in conditions like Alzheimer's, Parkinson's, and ischemia.