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A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
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Published on: January 2, 2017

The pharmacokinetics of single dose intramuscular amoxicillin trihydrate in tammar wallabies (Macropus eugenii)

David J McLelland1, Brian G Rich, Peter H Holz

  • 1University of Guelph, Guelph, Ontario N1G 2W1, Canada. dmclelland@zoossa.com.au

Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians
|April 17, 2009
PubMed

Five tammar wallabies (Macropus eugenii) were injected intramuscularly with 10 mg/kg amoxicillin trihydrate. Serial blood samples were collected through to 26 hr postinjection. Plasma amoxicillin concentrations were measured using high-performance liquid chromatography. Pharmacokinetic parameters were estimated using noncompartmental analysis. The terminal half-life (1.77 +/- 0.40 hr) was comparable to that previously reported in domestic small ruminants. Without intravenous kinetic data, it is unclear whether the terminal phase is elimination- or absorption-dependent; both scenarios have been reported in domestic species. Plasma concentrations of amoxicillin remained above a reported minimum inhibitory concentration (MIC) breakpoint for staphylococci and streptococci for at least 8 hr; the MIC breakpoint for enterobacteria and enterococci was never attained.

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