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Generation of Human Chimeric Antigen Receptor Regulatory T Cells
Published on: January 3, 2025
The companions: regulatory T cells and gene therapy
Saman Eghtesad1, Penelope A Morel, Paula R Clemens
1Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Abstract:
Undesired immunological responses to products of therapeutic gene replacement have been obstacles to successful gene therapy. Understanding such responses of the host immune system to achieve immunological tolerance to a transferred gene product is therefore crucial. In this article, we review relevant studies of immunological responses to gene replacement therapy, the role of immunological tolerance mediated by regulatory T cells in down-regulating the unwanted immune responses, and the interrelationship of the two topics.
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