Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Feedback Inhibition00:46

Feedback Inhibition

Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Age-related differences in motor learning, sensorimotor neurochemistry, and cortical reactivity co-occur but are dissociated.

Neurobiology of aging·2026
Same author

Youth Soccer Participation and Brain Health Outcomes in Adolescent Athletes.

JAMA network open·2026
Same author

Effects of high-intensity and blood-flow-restricted resistance training on tendon adaptations in older men.

European journal of applied physiology·2026
Same author

Characterisation of the axon initial segment and intrinsic excitability in the sub-acute phase post-ischaemic stroke.

Brain communications·2026
Same author

Cortico-cortical paired associative stimulation increases SMA-M1 facilitation in tremor-dominant Parkinson's disease.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same author

Neural correlates of handgrip strength asymmetry in normal aging and older adults with mild cognitive impairment.

Brain research·2026

Related Experiment Video

Updated: Jun 24, 2026

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention
09:48

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

Published on: September 11, 2017

Age-related differences in inhibitory processes during interlimb coordination.

Hakuei Fujiyama1, Mike I Garry, Oron Levin

  • 1Human Motor Control Laboratory, School of Psychology, University of Tasmania, Hobart, Tasmania 7001, Australia.

Brain Research
|April 17, 2009
PubMed
Summary
This summary is machine-generated.

Older adults exhibit reduced coordination stability and altered motor control, particularly in complex hand-foot movements. This age-related decline may stem from diminished inhibitory functions in the nervous system.

More Related Videos

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

Monitoring Fine and Associative Motor Learning in Mice Using the Erasmus Ladder
08:51

Monitoring Fine and Associative Motor Learning in Mice Using the Erasmus Ladder

Published on: December 15, 2023

Related Experiment Videos

Last Updated: Jun 24, 2026

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention
09:48

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

Published on: September 11, 2017

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

Monitoring Fine and Associative Motor Learning in Mice Using the Erasmus Ladder
08:51

Monitoring Fine and Associative Motor Learning in Mice Using the Erasmus Ladder

Published on: December 15, 2023

Area of Science:

  • Neuroscience
  • Motor Control
  • Human Aging

Background:

  • Interlimb coordination is crucial for complex motor tasks.
  • Age-related declines in motor performance are well-documented.
  • Understanding the neurophysiological basis of these changes is essential.

Purpose of the Study:

  • To investigate the neurophysiological mechanisms underlying age-related changes in hand-foot movement coordination.
  • To compare motor control strategies between young and older adults during various coordination tasks.

Main Methods:

  • Participants: 30 young and older adults.
  • Tasks: Cyclical isodirectional and non-isodirectional hand-foot movements (contralateral and ipsilateral limbs).
  • Measurements: Motor evoked potentials (MEPs) and silent period durations from the ECR muscle using transcranial magnetic stimulation (TMS).

Main Results:

  • Older adults showed lower coordination stability, especially with ipsilateral, non-isodirectional movements.
  • MEP amplitude was reduced in older adults across all tasks.
  • Young adults exhibited longer silent periods during ipsilateral coordination, unlike older adults.

Conclusions:

  • Age-related motor performance decline is linked to impaired interlimb coordination.
  • Reduced ability to modulate inhibitory neural function may underlie these age-related motor deficits.
  • Findings highlight the impact of aging on the central nervous system's control of movement.