Related Experiment Video
Updated: Jun 24, 2026
08:17
Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
Published on: June 7, 2015
Improvement in tumour control probability with active breathing control and dose escalation: a modelling study
Mike Partridge1, Alison Tree, Juliet Brock
1Institute of Cancer Research, Sutton, UK. m.partridge@physics.org
Summary
Deep inspiration breath-hold techniques allow for dose escalation in non-small cell lung cancer radiotherapy. This significantly increases tumor control probability without raising the radiation dose to the lungs.
Area of Science:
- Radiation Oncology
- Medical Physics
Background:
- Non-small cell lung cancer (NSCLC) prognosis is poor, with radiotherapy local control limited by normal tissue sensitivity.
- High tumor doses required for radical radiotherapy are constrained by normal structure irradiation tolerance.
Purpose of the Study:
- To evaluate the potential increase in tumor control probability (TCP) through dose escalation.
- To assess the feasibility of dose escalation using moderate deep inspiration breath-hold (DIBH).
Main Methods:
- Retrospective analysis of 28 NSCLC patients from two studies.
- Treatment planning with and without DIBH using an active breathing control (ABC) device.
- Dose escalation to a maximum of 84 Gy while maintaining Mean Lung Dose (MLD) and normal tissue tolerances.
Main Results:
- Prescription dose escalated from 64 Gy to a mean of 73.7 Gy.
- Tumor control probability significantly increased from 0.15 to 0.29 (p<0.0001).
- No statistical difference in results whether bilateral or ipsilateral lung data was used.
Conclusions:
- Modest dose escalation via DIBH can nearly double TCP.
- This escalation is achievable without increasing lung dose.
- DIBH techniques are effective for improving NSCLC radiotherapy outcomes.
