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Related Experiment Video

Updated: Jun 24, 2026

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

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Published on: February 9, 2021

Thiosulfate reduces calcium phosphate nephrolithiasis.

John R Asplin¹, Susan E Donahue, Christina Lindeman

¹Litholink Corp., 2250 W. Campbell Park Drive, Chicago, IL 60612, USA. jasplin@litholink.com

Journal of the American Society of Nephrology : JASN

|April 17, 2009

Summary

This summary is machine-generated.

Sodium thiosulfate significantly reduced calcium phosphate kidney stone formation in a rat model. Further controlled human trials are necessary to confirm its efficacy and safety for preventing recurrent kidney stones.

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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

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Published on: June 2, 2022

Area of Science:

Nephrology
Urology
Biochemistry

Background:

Recurrent kidney stones pose a significant health burden.
Sodium thiosulfate has shown potential in reducing calcium kidney stone formation in uncontrolled human trials.
Controlled studies in animal models are needed to validate these findings.

Purpose of the Study:

To investigate the effect of sodium thiosulfate on calcium phosphate kidney stone formation.
To analyze urine chemistry and supersaturation in a genetic hypercalciuric rat model.

Main Methods:

Genetic hypercalciuric rats were fed a standard diet with or without sodium thiosulfate for 18 weeks.
Urine chemistries, supersaturation, and metastability were measured.
In vitro experiments assessed thiosulfate's effect on ionized calcium.

Main Results:

Sodium thiosulfate treatment significantly reduced stone formation (3/12 rats) compared to controls (11/12 rats).
While some urine parameters changed, overall calcium phosphate supersaturation and metastability did not significantly differ between groups.
Thiosulfate minimally affected ionized calcium in vitro, suggesting a non-chelating mechanism.

Conclusions:

Sodium thiosulfate effectively reduces calcium phosphate kidney stone formation in the genetic hypercalciuric rat model.
The precise mechanism of action requires further investigation.
Controlled human trials are warranted to evaluate the efficacy and safety of sodium thiosulfate for preventing recurrent kidney stones.