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Updated: Jun 24, 2026

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)
Published on: January 7, 2018
Oral hypoglycaemic agents, insulin resistance and cardiovascular disease in patients with type 2 diabetes
Bianca Hemmingsen1, Søren S Lund, Jørn Wetterslev
1Copenhagen Trial Unit, Rigshospitalet, 2100 Copenhagen Ø, Denmark Steno Diabetes Center, Niels Steensensvej 2-4, 2820 Gentofte, Denmark. biancahemmingsen@hotmail.com
Abstract:
This article is a narrative review of the current evidence of the effects on cardiovascular disease (CVD) of oral hypoglycaemic agents that increase insulin sensitivity in patients with type 2 diabetes (T2D). In overweight T2D patients, metformin has been demonstrated to reduce CVD risk, and this beneficial effect may be conserved with the combination of metformin and insulin treatment. However, the effect of glitazones on CVD is uncertain. There is conflicting evidence from large randomized trials to support a protective effect against CVD of lowering blood glucose per se but a systematic review with meta-analysis is lacking. It may be reasonable to aim for an intervention targeting multiple CVD risk factors such as dyslipidaemia, hypertension and albuminuria in T2D patients.
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