Two cases of failed ceftriaxone treatment in pharyngeal gonorrhoea verified by molecular microbiological methods
John Tapsall1, Phillip Read2, Christopher Carmody3
1World Health Organization Collaborating Centre for STD, Prince of Wales Hospital, Sydney, Australia.
Abstract:
Diagnostic, genotypic and antibiotic-resistance determinants of Neisseria gonorrhoeae were analysed by molecular methods to verify the failure of ceftriaxone treatment in two cases of pharyngeal gonorrhoea. Monoplex assays were needed to define competitive inhibition of a positive Chlamydia PCR in a duplex assay. Different penA changes were detected in the N. gonorrhoeae isolated from the two cases. These were associated with raised ceftriaxone MICs of 0.03 and 0.016 mg l(-1), which may have contributed to the treatment failures in these cases.
Related Concept Videos
Mechanism of Antibiotic Resistance in MRSA
Streptococcal Pharyngitis
Acute Pharyngitis
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Urine Studies II: Urine Culture and Sensitivity Test
Inhibitors of Bacterial DNA Synthesis
Bacterial Phylum Chlamydiae
