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Calcifying pseudoneoplasms of the neuraxis: CT, MR imaging, and histologic features
1Department of Radiology, University of California, San Francisco, Calif., USA. Ashley.aiken@radiology.ucsf.edu
AJNR. American Journal of Neuroradiology
|April 17, 2009
Summary
Calcifying pseudoneoplasms of the neuraxis (CAPNON) are rare, non-neoplastic lesions. Imaging reveals T1/T2 hypointensity and dense calcification, aiding diagnosis.
Area of Science:
- Neuroradiology
- Pathology
- Neuro-oncology
Background:
- Calcifying pseudoneoplasms of the neuraxis (CAPNON) are rare, non-neoplastic, calcified, fibro-osseous lesions.
- Their radiologic and histopathologic characteristics are not well understood.
- This study presents the largest series reviewing MR imaging features of CAPNON.
Observation:
- Retrospective review of MR and CT imaging features in 4 patients with CAPNON.
- Histopathologic features were analyzed for typical and atypical patterns.
- Imaging findings were strikingly similar across all 4 patients.
Findings:
- Lesions appeared T1 and T2 hypointense without vasogenic edema.
- All tumors demonstrated dense calcification.
- Three tumors showed minimal linear internal or rim enhancement on MR imaging.
Implications:
- CAPNON can mimic vascular malformations or neoplasms, often overlooked in differential diagnoses.
- Consider CAPNON in the differential diagnosis of calcified masses with marked T1/T2 hypointensity and minimal enhancement.
- Preoperative recognition via CT and MR imaging can aid subsequent management decisions.
