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Updated: Jun 24, 2026

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence
Published on: December 30, 2025
Proteins involved in pRb and p53 pathways are differentially expressed in thin and thick superficial spreading
Bianca Costa Soares de Sá1, Melissa Lissae Fugimori, Karina de Cássia Braga Ribeiro
1Department of Skin Oncology, Hospital AC Camargo, São Paulo, Brazil. bianca.sa@terra.com.br
Abstract:
Cutaneous melanoma is one of the leading causes of cancer-related death. Malignant transformation of epidermal melanocytes is a multifactorial process involving cell cycle and death control pathways. The purpose of this study was to analyze the immunohistochemical expression of cell-cycle-related and apoptosis-related proteins in cutaneous superficial spreading melanomas using the tissue microarray technique to further understand tumor development. A total of 20 samples of in-situ melanomas and 44 melanomas
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