Related Experiment Video
Updated: Jun 24, 2026

Standard Test Method ASTM D 7998-19 for the Cohesive Strength Development of Wood Adhesives
Published on: May 17, 2020
Shear-bond strength between a new format of intra-buccal acrylic bioadhesive drug delivery system and adhesive
V Pedrazzi1, J O Del Ciampo, H Panzeri
1Department of Dental Materials and Prosthodontics, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo, Brazil. pedrazzi@forp.usp.br
Aim:
An intra-buccal acrylic bioadhesive device designated for drug programmed release that can stay adhered to dental enamel, and also on removable prosthetic restorations, with preventive and/or therapeutic purpose for a large clinical applications based on polymethyl methacrylate/methyl methacrylate/2 hydroxyethyl methacrylate (PMMA/MMA/HEMA) was developed, using the sodium fluoride as an active principle. This bioadhesive was evaluated for its shear bond strength when bonded with different adhesive systems.
Methods:
Two substrates (recently extracted human teeth and acrylic prosthesis basis) were used to obtain the 96 test-specimens. Four adhesive systems (Cyanoacrylate ester, 3M Concise Enamel Bond Resin with or without previous enamel etching, MMA/HEMA or PMMA/MMA/ HEMA) were chosen for the fixation of the bioadhesives to substrate. Artificial saliva or distilled water was used as medium for maintaining the specimens until test.
Results:
Statistical analysis showed that the interaction bioadhesives/acrylic prosthesis basis/cyanoacrylate ester adhesive was the most resistant to the physical removal by shearing.
Conclusion:
The newly rounded semi-convex format of acrylic device developed in this study presented satisfactory shear bond strength and might contribute to the comfort of intra-buccal use.
Related Concept Videos
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Oral Drug Delivery Systems: Delayed-Release Systems
Ophthalmic Drug Delivery Systems
Modified-Release Drug Delivery Systems: Stimuli-Activated
Oral Drug Delivery Systems: Introduction
Modified-Release Drug Delivery Systems: Rate-Programmed I
