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Related Experiment Video

Updated: Jun 24, 2026

Fully Automated Centrifugal Microfluidic Device for Ultrasensitive Protein Detection from Whole Blood
08:58

Fully Automated Centrifugal Microfluidic Device for Ultrasensitive Protein Detection from Whole Blood

Published on: April 16, 2016

Micromagnetic-microfluidic blood cleansing device.

Chong Wing Yung1, Jason Fiering, Andrew J Mueller

  • 1Vascular Biology Program, Department of Surgery and Pathology, Children's Hospital and Harvard Medical School, 300 Longwood Ave., KFRL 11.127, Boston, MA 02115-5737, USA.

Lab on a Chip
|April 17, 2009
PubMed
Summary
This summary is machine-generated.

This study introduces a novel micromagnetic-microfluidic device for extracorporeal blood cleansing, effectively removing Candida albicans to improve sepsis treatment. The device offers a promising new approach to combat bloodstream infections and enhance antibiotic therapy efficacy.

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Last Updated: Jun 24, 2026

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Area of Science:

  • Biomedical Engineering
  • Infectious Diseases
  • Medical Devices

Background:

  • Sepsis is a life-threatening condition caused by systemic microbial infections spreading through the bloodstream.
  • Current sepsis treatments are often insufficient, failing to eliminate pathogens and toxins, leading to suboptimal patient outcomes.
  • Candida albicans is a major fungal pathogen responsible for significant sepsis-related mortality.

Purpose of the Study:

  • To develop and evaluate an extracorporeal blood cleansing device for selective pathogen removal.
  • To enhance the effectiveness of antibiotic therapy in sepsis patients by eliminating microbial sources.
  • To demonstrate the feasibility of micromagnetic-microfluidic technology for high-throughput blood pathogen clearance.

Main Methods:

  • Modification of immunomagnetic microbeads into magnetic opsonins for pathogen capture.
  • Development of a micromagnetic-microfluidic device with vertically stacked channels and magnetic field gradients.
  • Continuous cleansing of flowing human whole blood contaminated with Candida albicans.
  • Testing of a multiplexed device with four parallel channels for enhanced throughput.

Main Results:

  • The device successfully captured and removed Candida albicans from human whole blood.
  • A multiplexed version achieved over 80% clearance of fungi in a single pass at a flow rate of 20 mL/h.
  • The achieved flow rate is 1000 times faster than previous micromagnetic-microfluidic separation systems.
  • Demonstrated proof-of-principle for clinical relevance in blood pathogen cleansing.

Conclusions:

  • The micromagnetic-microfluidic blood cleansing device shows significant potential for treating sepsis by removing pathogens.
  • This technology offers a high-throughput and efficient method for extracorporeal blood purification.
  • The findings support the clinical applicability of this novel approach for managing bloodstream infections.