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Updated: Jun 24, 2026
05:31
Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
Published on: June 8, 2022
[Percutaneous aortic valve implantation - contra].
Klaus Kallenbach1, Matthias Karck
1Klinik für Herzchirurgie, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany. Klaus.kallenbach@med.uniheidelberg.de
Herz
|April 17, 2009
Summary
Open heart surgery for aortic valve replacement (AVR) is the gold standard for severe aortic stenosis. Transcatheter aortic valve implantation (PAVI) is expanding to higher-risk patients, but requires more research on long-term outcomes and complications.
Area of Science:
- Cardiovascular Surgery
- Interventional Cardiology
- Biomedical Engineering
Context:
- Severe aortic stenosis necessitates intervention, with open-heart aortic valve replacement (AVR) as the established gold standard.
- Transcatheter aortic valve implantation (PAVI) emerged for inoperable patients but its indications are expanding.
- Patient selection for PAVI increasingly relies on risk scores, though their accuracy is debated.
Purpose:
- To review the current status of aortic valve replacement (AVR) and percutaneous aortic valve implantation (PAVI).
- To discuss the evolving indications for PAVI and its associated risks and benefits.
- To highlight the need for further research comparing PAVI and AVR.
Summary:
- AVR offers excellent long-term results for severe aortic stenosis, even in the elderly.
- PAVI, initially for inoperable patients, is now considered for high-risk surgical candidates, but carries significant periprocedural risks.
- Complications of PAVI include graft dislocation, aortic rupture, coronary ostia obstruction, and perivalvular insufficiency.
Impact:
- PAVI's expanding indications require careful patient selection and multidisciplinary teams.
- Long-term durability and safety of PAVI valves remain uncertain, necessitating randomized trials.
- Further research is crucial to define PAVI's role relative to AVR and optimize patient outcomes.
