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Assisted hatching on assisted conception (IVF and ICSI).

Sangeeta Das¹, Debbie Blake, Cindy Farquhar

¹St Mary's Hospital, Hathersage Road, Manchester, UK.

The Cochrane Database of Systematic Reviews

|April 17, 2009

Summary

This summary is machine-generated.

Assisted hatching (AH) may improve clinical pregnancy rates in fertility treatments, but does not significantly increase live births. AH also leads to a significant increase in multiple pregnancy rates.

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Area of Science:

Reproductive Medicine
Embryology
Infertility Treatment

Background:

Implantation failure can stem from the blastocyst's inability to exit the zona pellucida.
Assisted hatching (AH) artificially disrupts the zona pellucida to improve conception success.

Purpose of the Study:

To evaluate the efficacy of assisted hatching (AH) in facilitating live births and clinical pregnancies.

Main Methods:

Systematic review and meta-analysis of randomized controlled trials (RCTs) comparing AH with no AH.
Searched multiple databases including Cochrane, MEDLINE, and EMBASE up to February 2007.
Included RCTs reporting live birth or clinical pregnancy rates, with independent data extraction and assessment.

Main Results:

No significant difference in live birth rates between AH and control groups.
A statistically significant increase in clinical pregnancy rates was observed with AH (OR 1.29).
Multiple pregnancy rates were significantly higher in the AH group (OR 1.67).

Conclusions:

Assisted hatching may enhance clinical pregnancy rates, potentially increasing a 25% success rate to 29-49%.
Insufficient data exists to determine AH's impact on other critical outcomes.
Increased multiple pregnancy rates warrant careful consideration in clinical practice.