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Updated: Jun 24, 2026

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness
09:17

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness

Published on: May 2, 2017

Nutritional support for critically ill children.

Ari Joffe1, Natalie Anton, Laurance Lequier

  • 1Department of Pediatrics, Division of Pediatric Intensive Care, University of Alberta and Stollery Children's Hospital, Office 3A3.07, 8440- 112 St, Edmonton, Alberta, Canada, T6G 2B7. ajoffe@cha.ab.ca

The Cochrane Database of Systematic Reviews
|April 17, 2009
PubMed
Summary
This summary is machine-generated.

Limited research exists on nutritional support for critically ill children. One trial found no significant differences in outcomes between early and delayed enteral nutrition, highlighting the urgent need for more studies on pediatric nutrition guidelines.

Related Experiment Videos

Last Updated: Jun 24, 2026

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness
09:17

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness

Published on: May 2, 2017

Area of Science:

  • Pediatric Intensive Care
  • Clinical Nutrition
  • Evidence-Based Medicine

Background:

  • Nutritional support for critically ill children is under-researched and lacks clear guidelines.
  • Optimal timing and methods for nutrition in pediatric intensive care remain controversial.
  • Existing evidence on enteral and parenteral nutrition in this population is limited.

Purpose of the Study:

  • To evaluate the impact of enteral nutrition versus total parenteral nutrition on key outcomes in critically ill children.
  • To synthesize evidence from randomized controlled trials on pediatric nutritional support.

Main Methods:

  • Comprehensive literature search across multiple databases (Cochrane, MEDLINE, EMBASE, etc.) and trial registries.
  • Inclusion of randomized controlled trials involving pediatric patients (1 day to 18 years) in pediatric intensive care units (PICUs).
  • Focus on studies reporting clinically important outcomes like mortality, length of stay, and complications.

Main Results:

  • Only one relevant randomized trial was identified, involving 77 pediatric burn patients.
  • The trial compared enteral nutrition within 24 hours versus after 48 hours, finding no significant differences in mortality, sepsis, or length of stay.
  • The identified trial was of low methodological quality with an unclear risk of bias.

Conclusions:

  • The current evidence base is insufficient to establish best practices for nutritional support in critically ill children.
  • There is an urgent need for high-quality research to guide nutritional strategies in pediatric intensive care.
  • Further studies are required to determine optimal timing and forms of nutrition for this vulnerable patient group.