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Related Concept Videos

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Related Experiment Video

Updated: Jun 24, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Interventions for improving adherence to ocular hypotensive therapy.

Trish A Gray1, Lois C Orton, David Henson

  • 1Academic Department of Ophthalmology, Manchester Royal Eye Hospital, Oxford Road, Manchester, UK, M13 9WH. trish.gray@manchester.ac.uk

The Cochrane Database of Systematic Reviews
|April 17, 2009
PubMed
Summary
This summary is machine-generated.

Improving adherence to ocular hypotensive therapy for glaucoma patients is crucial. Simplified drop schedules and reminder devices show promise, but more high-quality research is needed to confirm effectiveness.

Related Experiment Videos

Last Updated: Jun 24, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Area of Science:

  • Ophthalmology
  • Pharmacology
  • Health Services Research

Background:

  • Poor adherence to ocular hypotensive therapy is a significant issue in managing open-angle glaucoma.
  • Treatment failure due to non-adherence can lead to increased healthcare costs and potential need for surgery.
  • Simplifying treatment regimens, providing patient education, and offering ongoing support may improve adherence.

Purpose of the Study:

  • To systematically review interventions aimed at enhancing patient adherence to ocular hypotensive therapy for individuals with ocular hypertension (OHT) or glaucoma.

Main Methods:

  • Conducted a comprehensive literature search across multiple databases (e.g., CENTRAL, MEDLINE, EMBASE) and ongoing trial registers.
  • Included randomized controlled trials (RCTs) and quasi-RCTs evaluating interventions to improve adherence to ocular hypotensive therapy.
  • Independently assessed study eligibility and extracted data; meta-analysis was performed where appropriate using fixed-effect models.

Main Results:

  • Eight trials met the inclusion criteria, but significant heterogeneity in interventions and outcomes limited meta-analysis to two studies.
  • Studies generally suffered from methodological limitations, including small sample sizes and short follow-up periods.
  • Evidence suggested that simplifying drop frequency, using reminder devices, and implementing individualized care plans could improve adherence, though results were not consistently significant across all studies.

Conclusions:

  • Interventions such as simplified dosing, reminder aids, patient education, and tailored care planning demonstrated potential for improving adherence rates in glaucoma patients.
  • However, due to the heterogeneity and methodological weaknesses of the included studies, definitive recommendations for specific interventions cannot be made at this time.