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Maintenance treatments for opiate dependent adolescent.
Silvia Minozzi1, Laura Amato, Marina Davoli
1Department of Epidemiology, ASL RM/E, Via di Santa Costanza, 53, Rome, Italy, 00198. sminozzi1@alice.it
The Cochrane Database of Systematic Reviews
|April 17, 2009
Summary
Pharmacological maintenance treatment for adolescent opioid dependence shows promise in retaining patients and reducing opioid use. However, evidence is limited due to few studies and ethical challenges in adolescent research.
Area of Science:
- Addiction Medicine
- Adolescent Psychiatry
- Pharmacology
Background:
- Pharmacotherapy is crucial for adult opioid dependence treatment.
- Limited research exists on pharmacological maintenance for adolescents.
Purpose of the Study:
- Assess maintenance treatment effectiveness in adolescents.
- Compare interventions for retention, substance use, and health/social status.
Main Methods:
- Systematic review of randomized controlled trials.
- Searched multiple databases up to August 2008.
- Included trials on adolescents (13-18 years).
Main Results:
- Two trials (187 participants) were included.
- Maintenance treatment improved retention and reduced self-reported opioid use at 1 year.
- No significant reduction in positive urine tests at study end.
Conclusions:
- Evidence is limited due to only two trials.
- Ethical and practical challenges hinder adolescent research.
- Further research is needed to confirm findings.
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