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Occurrence of sesquiterpene derivatives in Scleria striatonux de wild (Cyperaceae)
Kennedy Nyongbela1, Karine Ioset Ndjoko, Reto Brun
1Laboratoire de Pharmacognosie et Phytochimie, Ecole de Pharmacie Genève, Université de Genève, Quai Ansermet 30, 1211 Genève 4, Switzerland.
Abstract:
Scleria striatonux (Cyperaceae), a spice traditionally used in Cameroon, displayed an antiplasmodial activity. Two new sesquiterpenes, 1 (sclerienone A) and 2 (sclerienone B), have subsequently been isolated from the methylene chloride/methanol extract of the rhizome. Their separation involved a combination of methods including repeated silica gel open column chromatography, Sephadex LH-20 and semi-preparative HPLC. Structure elucidation was achieved by means of chemical tests and extensive spectral studies.
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