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Micro-albuminuria: a predictor of short-term mortality in acute ischaemic stroke

Soumitra Ghosh1, Sanjay Kumar Bandyopadhyay, Ranjana Bandyopadhyay

  • 1Department of Medicine, Midnapore Medical College, Paschim Medinipur.

Journal of the Indian Medical Association
|April 18, 2009
PubMed

Insights

Micro-albuminuria (MA) is prevalent in acute ischemic stroke patients and predicts higher in-hospital mortality. Early detection of MA can help identify high-risk stroke patients for closer monitoring and intervention.

Area of Science:

  • Nephrology
  • Neurology
  • Clinical Medicine

Background:

  • Micro-albuminuria (MA) is an early marker of kidney disease and cardiovascular risk.
  • Its role in predicting outcomes in acute ischemic stroke is not well-established.

Purpose of the Study:

  • To investigate the prevalence of MA in acute ischemic stroke patients.
  • To determine if MA predicts short-term in-hospital mortality in this population.

Main Methods:

  • A prospective study of 89 acute ischemic stroke patients, 70 with chronic neurological diseases, and 60 healthy controls.
  • Urinary albumin-to-creatinine ratio (MA) measured on days 1, 4, and/or 7.
  • Functional status assessed using NIH Stroke Scale (NIHSS); 14-day mortality recorded.

Main Results:

  • MA prevalence was significantly higher in acute ischemic stroke patients (61.79%) compared to controls (13%-7%).
  • Patients with MA were older, had higher systolic blood pressure, and experienced higher 14-day mortality (25.45% vs. 5.88%).
  • High day 1 MA and increasing MA levels correlated with increased mortality and higher NIHSS scores.

Conclusions:

  • MA is a common finding in acute ischemic stroke.
  • MA is a reliable predictor of short-term in-hospital mortality in acute ischemic stroke patients.
  • MA assessment may aid in risk stratification and management of acute ischemic stroke.

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