Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Another cholesterol hypothesis: cholesterol as antioxidant.

L L Smith1

  • 1Department of Human Biological Chemistry & Genetics, University of Texas Medical Branch, Galveston 77550.

Free Radical Biology & Medicine
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implementing a participant-driven water management initiative to support Maryland hospitals.

Infection prevention in practice·2026
Same author

Open space, not reduced herbivory, facilitates invasion of a marine macroalga, implying it is a disturbance-mediated "passenger" of change.

Marine environmental research·2021
Same author

Pathogenicity Assessment of Puccinia lygodii, a Potential Biological Control Agent of Lygodium japonicum in Southeastern United States.

Plant disease·2019
Same author

Growth promoting hormonal implant pellets coated with a polymeric, porous film promote weight gain by grazing beef heifers and steers for up to 200 days.

Journal of animal science·2015
Same author

Pharmacokinetics and selected pharmacodynamics of cobalt following a single intravenous administration to horses.

Drug testing and analysis·2014
Same author

Combination anthelmintics effectively control ML-resistant parasites; a real-world case history.

Veterinary parasitology·2014

Cholesterol

Area of Science:

  • Biochemistry
  • Cardiovascular Science
  • Oxidative Stress Biology

Background:

  • Current research often highlights cholesterol's role in atherosclerosis and cardiovascular disease.
  • The essential biological functions of cholesterol are frequently overlooked.
  • Low levels of oxidized cholesterol derivatives (oxysterols) are present in blood and tissues, also linked to atherosclerosis.

Purpose of the Study:

  • To propose an alternative view of certain oxysterols found in human blood.
  • To investigate the role of cholesterol in metabolizing oxidants as an in vivo antioxidant system.

Main Methods:

  • Review of existing literature on cholesterol metabolism and oxidative stress.
  • Analysis of the proposed role of B-ring oxidized oxysterols in antioxidant defense.

Related Experiment Videos

  • Consideration of hepatic metabolism, biliary secretion, and fecal excretion pathways.

    • Main Results:

    • Some oxysterols, specifically B-ring oxidized forms, may represent cholesterol's natural interception of oxidants.
    • This process, followed by hepatic metabolism and excretion, suggests an endogenous antioxidant system.
    • The precise contribution of cholesterol, oxysterols, and oxidized lipoproteins to atherosclerosis requires further investigation.

    Conclusions:

    • Cholesterol's role in metabolizing oxidants may function as an in vivo antioxidant system.
    • The implication of oxysterols in atherosclerosis warrants a nuanced understanding beyond solely detrimental effects.
    • Further research is needed to elucidate the complex interplay between cholesterol metabolism, oxidative stress, and cardiovascular disease pathogenesis.