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Glial Cells

Glial Cells

Nervous Tissue: Glial Cells

Nervous Tissue: Glial Cells

Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
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Related Experiment Video

Updated: Jun 23, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Galectins and gliomas.

Marie Le Mercier¹, Shannon Fortin, Véronique Mathieu

¹Laboratory of Toxicology; Institute of Pharmacy, Universite Libre de Bruxelles, Brussels, Belgium.

Brain Pathology (Zurich, Switzerland)

|April 18, 2009

Summary

Malignant gliomas like glioblastoma have poor prognoses due to invasive growth and drug resistance. Galectins, particularly galectin-1 and galectin-3, are key players in glioma progression and may be therapeutic targets.

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Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

Area of Science:

Neuro-oncology
Molecular Biology
Cancer Research

Background:

Malignant gliomas, particularly glioblastomas, present a poor prognosis with limited median survival.
Glioma cell infiltration and apoptosis resistance contribute to therapeutic challenges.
Galectins, beta-galactoside-binding proteins, are implicated in various cellular processes, including cancer.

Purpose of the Study:

To review the role of galectins, specifically galectin-1 and galectin-3, in glioma biology.
To explore galectin involvement in glioma progression mechanisms.
To assess galectins as potential therapeutic targets for malignant gliomas.

Main Methods:

Literature review focusing on galectin expression and function in gliomas.
Analysis of galectin roles in glioma cell migration, angiogenesis, and chemoresistance.
Synthesis of current knowledge on galectins in glioma pathogenesis.

Main Results:

Galectins, especially galectin-1 and galectin-3, are differentially expressed in gliomas.
These galectins are involved in critical steps of glioma progression, including invasion and vascularization.
Galectins contribute to resistance against chemotherapy in glioma cells.

Conclusions:

Galectin-1 and galectin-3 play significant roles in malignant glioma progression.
Targeting galectins may offer a novel therapeutic strategy for glioblastoma.
Further research into galectin-targeted therapies is warranted for improved glioma treatment.