IL-17 and Th17 cells in human inflammatory diseases

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Updated: Jun 23, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Pierre Miossec1

  • 1Department of Immunology and Rheumatology, Hôpital Edouard Herriot and Immunogenomics and inflammation research unit EA 4130, University of Lyon; Lyon, France. miossec@univ-lyon1.fr

Microbes and Infection
|April 18, 2009
PubMed

IL-17 was discovered in 1995/96 as a T cell derived cytokine with effects on inflammation and neutrophil activation. In 2006, the precise cell source of IL-17 was identified in the mouse, and these cells were named Th17 cells. They play a role in various human diseases associated with inflammation and destruction such as rheumatoid arthritis, psoriasis, Crohn's disease, multiple sclerosis, where IL-17 can be seen as a therapeutic target.

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