Related Experiment Video
Updated: Jun 23, 2026
07:13
Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
Published on: April 12, 2021
Bone disease in kidney transplant patients
Minna Huang1, Stuart M Sprague
1Division of Nephrology and Hypertension, NorthShore University HealthSystem, Northwestern University Feinberg School of Medicine, Evanston, IL, USA.
Seminars in Nephrology
|April 18, 2009
Summary
Managing bone disease after a kidney transplant is challenging due to its complex causes. Current treatments may improve bone density but not always reduce fracture risk in kidney disease patients.
Area of Science:
- Nephrology
- Endocrinology
- Bone Metabolism
Background:
- Chronic kidney disease (CKD) and end-stage kidney disease (ESKD) severely disrupt bone and mineral metabolism.
- Posttransplantation bone disease (PTBD) is a significant complication in long-term kidney transplant survivors.
Purpose of the Study:
- To highlight the challenges in managing PTBD.
- To underscore the importance of evaluating and managing PTBD in post-transplant care.
Main Methods:
- Review of current understanding of PTBD pathophysiology.
- Analysis of therapeutic options and their impact on bone mineral density and fracture risk.
Main Results:
- PTBD management is complicated by its complex pathophysiology.
- Therapeutic interventions may improve bone mineral density but not consistently reduce fracture risk.
Conclusions:
- Effective evaluation and management of PTBD are crucial components of post-kidney transplant care.
- Further research is needed to identify treatments that effectively decrease fracture risk in these patients.
Related Concept Videos
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
01:16Kidney Transplant III: Nursing Management
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
01:26Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
01:24Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
01:22Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
01:25Chronic Kidney Disease I: Introduction
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...