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Fibrous dysplasia: a systematic review
1Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada. dmacdon@interchange.ubc.ca
Dento Maxillo Facial Radiology
|April 18, 2009
Summary
Fibrous dysplasia (FD) most commonly presents as jaw swelling, equally affects both genders, and is more prevalent in the maxilla. Long-term follow-up is needed as FD can reactivate, even after adolescence.
Area of Science:
- Oral and Maxillofacial Surgery
- Pathology
- Radiology
Background:
- Fibrous dysplasia (FD) is a bone disorder characterized by the replacement of normal bone with fibrous tissue and immature bone.
- Understanding the epidemiological and clinical features of FD is crucial for diagnosis and management.
Purpose of the Study:
- To systematically review the principal features of fibrous dysplasia.
- To compare the frequencies of these features across four global groups.
Main Methods:
- Systematic review of 106 reports, including 788 histopathologically confirmed cases of FD.
- Inclusion criteria required series reports with radiographs and histopathological confirmation.
- Databases searched included PubMed (Medline) and LILACS.
Main Results:
- FD affects genders equally, with a 50% higher prevalence in the maxilla.
- Mean age at presentation is 24 years; peak incidence is in the second decade (63% male).
- The primary symptom is swelling (90%), with buccolingual expansion common; mandibular cases show inferior border displacement, maxillary cases involve the antrum. No ocular involvement or sarcomatous change observed.
Conclusions:
- Long-term outcome data for FD is limited due to insufficient long-term follow-up in reported series.
- FD may not resolve in adolescence as expected for a hamartoma, with evidence of reactivation in some cases.
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