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Updated: Jun 23, 2026
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
The effects of platelet transfusions evaluated using rotational thromboelastometry
Per Flisberg1, Malin Rundgren, Martin Engström
1Department of Anaesthesia and Intensive Care, Lund University Hospital, Lund, Sweden.
Background:
In this study, we assessed the immediate effects of platelet transfusion on whole blood coagulation.
Methods:
Ten thrombocytopenic patients given a single unit platelet transfusion of 200-300 x 10(9) platelets had their coagulation status assessed before and immediately after transfusion using rotational thromboelastometry.
Results:
Transfusion increased the median platelet count from 31.5 to 43.5 x 10(9)/L. Clot formation time decreased by 32% (P = 0.005), whereas maximum clot strength increased by 47% (P = 0.005).
Conclusion:
Statistically significant improvements in rotational thromboelastometry-measured parameters were observed in association with a mean increase of 12 x 109/L in platelet count after platelet transfusion in these patients.
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