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Related Experiment Video

Updated: Jun 23, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

The effects of platelet transfusions evaluated using rotational thromboelastometry.

Per Flisberg1, Malin Rundgren, Martin Engström

  • 1Department of Anaesthesia and Intensive Care, Lund University Hospital, Lund, Sweden.

Anesthesia and Analgesia
|April 18, 2009
PubMed
Summary

Platelet transfusions rapidly improve blood clotting in thrombocytopenic patients. This study shows significant enhancements in clot formation time and strength after platelet therapy.

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Area of Science:

  • Hematology
  • Transfusion Medicine
  • Coagulation Science

Background:

  • Platelet transfusion is a common intervention for managing bleeding disorders.
  • Understanding the immediate impact of platelet transfusion on hemostasis is crucial for clinical practice.

Purpose of the Study:

  • To evaluate the acute effects of platelet transfusion on whole blood coagulation parameters.
  • To assess changes in coagulation status immediately following a single-unit platelet transfusion.

Main Methods:

  • Ten patients with thrombocytopenia received a single unit of platelets (200-300 x 10(9)).
  • Coagulation status was measured using rotational thromboelastometry (ROTEM) before and after transfusion.
  • Platelet counts were monitored to correlate with coagulation changes.

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Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Related Experiment Videos

Last Updated: Jun 23, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Main Results:

  • Platelet counts increased significantly, from a median of 31.5 to 43.5 x 10(9)/L.
  • Clot formation time decreased by 32% (P = 0.005), indicating faster clot initiation.
  • Maximum clot strength increased by 47% (P = 0.005), suggesting improved clot stability.

Conclusions:

  • Platelet transfusion leads to rapid and statistically significant improvements in whole blood coagulation.
  • ROTEM parameters demonstrate enhanced clot kinetics and strength post-transfusion.
  • A mean increase of 12 x 10(9)/L in platelet count was associated with these hemostatic improvements.