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Long-term toxicity/carcinogenicity study of calcium lactate in F344 rats
A Maekawa1, Y Matsushima, H Onodera
1Division of Pathology, Biological Safety Research Center, National Institute of Hygienic Sciences, Tokyo, Japan.
Abstract:
The long-term toxicity/carcinogenicity of calcium lactate, a food additive, was examined in F344 rats. Calcium lactate was given ad lib. in the drinking-water at levels of 0, 2.5 or 5% to groups of 50 male and 50 female rats for two years. No clear toxic lesion was specifically caused by long-term administration of calcium lactate. No significant dose-related increase was found in the incidences of tumours in any organ or tissue. The results indicated that calcium lactate had neither toxic nor carcinogenic activity in F344 rats.