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Related Concept Videos

Yellow Fever01:18

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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Related Experiment Video

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Screening of Axonal Degeneration in Carpal Tunnel Syndrome Using Ultrasonography and Nerve Conduction Studies
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Yellow nail syndrome.

Fabien Maldonado1, Jay H Ryu

  • 1Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.

Current Opinion in Pulmonary Medicine
|April 18, 2009
PubMed
Summary

Yellow nail syndrome (YNS) is a rare condition with unclear causes, affecting nails, lymphatic system, and lungs. Management focuses on symptom relief as no specific cure exists.

Area of Science:

  • Rare diseases
  • Dermatology
  • Pulmonology
  • Lymphology

Background:

  • Yellow nail syndrome (YNS) is a rare disorder characterized by distinct nail changes, lymphedema, and respiratory issues.
  • The exact cause of YNS remains unknown, contributing to diagnostic and therapeutic challenges.

Purpose of the Study:

  • To review the current understanding of yellow nail syndrome (YNS).
  • To focus on the diagnostic criteria and management strategies for YNS.

Main Methods:

  • Literature review of existing studies on yellow nail syndrome.
  • Analysis of clinical features, associations, and treatment outcomes.

Main Results:

  • Acquired lymphatic dysfunction is the likely primary mechanism in YNS.

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  • Clinical manifestations are variable and can change over time; associations with other disorders lack consistency.
  • Patient longevity is modestly reduced; supportive care is the primary management approach.

    • Conclusions:

    • The pathogenesis of YNS is not well-defined.
    • Diagnosis relies on characteristic clinical features: abnormal nails, lymphedema, and respiratory symptoms.
    • YNS typically follows a benign course, with management focused on alleviating symptoms.