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Related Concept Videos

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Downstream processing begins once fermentation is complete and involves a series of steps to recover and purify products such as acids, vitamins, antibiotics, or proteins.Cell HarvestingFor example, for intracellular protein-based products, the first step is harvesting the cells. This is typically achieved using centrifugation or filtration to separate the cells from the liquid phase.Cell Disruption for Intracellular ProductsIf the target product is intracellular, the harvested cells must be...
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Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...
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Related Experiment Video

Updated: Jun 23, 2026

Microfluidic Applications for Disposable Diagnostics
10:21

Microfluidic Applications for Disposable Diagnostics

Published on: February 3, 2008

Disposables in downstream processing.

Uwe Gottschalk1

  • 1Sartorius-Stedim Biotech GmbH, August-Spindler-Strasse 11, 37079, Goettingen, Germany, Uwe.Gottschalk@Sartorius-Stedim.com.

Advances in Biochemical Engineering/Biotechnology
|April 18, 2009
PubMed
Summary
This summary is machine-generated.

Disposable chromatography modules offer practical and economic advantages in downstream processing. These single-use systems reduce costs associated with cleaning, validation, and facility space, leading to lower overall manufacturing expenses.

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Area of Science:

  • Biotechnology
  • Chemical Engineering
  • Process Chemistry

Background:

  • Traditional downstream processing relies on fixed, reusable chromatography systems.
  • Growing interest in disposable technologies for improved efficiency and cost-effectiveness.
  • Disposable equipment is increasingly adopted beyond filtration and storage applications.

Purpose of the Study:

  • To examine the practical benefits of disposable modules in downstream processing.
  • To evaluate the economic advantages of implementing disposable chromatography systems.
  • To highlight the shift from fixed to disposable concepts in biopharmaceutical manufacturing.

Main Methods:

  • Review of current practices in downstream processing.
  • Analysis of cost-saving factors associated with disposable systems.
  • Comparison of fixed versus disposable chromatography module footprints and resource consumption.

Main Results:

  • Disposable chromatography modules offer significant savings in cleaning and validation.
  • Reduced footprints lead to lower consumption of buffers, water for injection, and facility space.
  • Overall reduction in operational expenditure and cost of goods.

Conclusions:

  • Disposable modules present a compelling alternative to traditional fixed systems in chromatography.
  • The adoption of disposable technology streamlines downstream processing and enhances economic viability.
  • Single-use chromatography is a key trend for optimizing biomanufacturing processes.