[A case of unstable diabetes mellitus after total pancreatectomy controlled by CSII]

Continuous subcutaneous insulin injection (CSII) is one of good methods to control unstable diabetes. In this paper, we reported a case of a patient with unstable diabetes after total pancreatectomy, to whom CSII was very effective. The case was 53 years of age, lean woman. In 1980, she had pancreatoduodenectomy for the treatment of cancer of duodenal papilla. In June, 1986, she was diagnosed as recurrence of the cancer, and undertaken total pancreatectomy. And then, insulin treatment was commended. But she readily developed hypoglycemic reactions by ordinary insulin injection once or twice a day, and glycemic control was very poor. On April 22, 1987, CSII was started. 8 units of regular insulin were given during 24 hours, and 2 units of regular insulin were added before every meal. Thereafter, the frequency of hypoglycemic reaction decreased dramatically, and HbA1c level decreased from 8.5% to 8.1% three months later. This report indicated usefulness of CSII to patients with unstable diabetes, who couldn't be controlled by ordinary insulin injection.