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[Administration of budesonide (inhaled steroid) to children to control intermittent asthma]
Hitzuri Ponce Castro1, Susana Rodríguez Espino, Alain R Rodríguez Orozco
1Especialista en Alergia e Inmunología, Hospital Infantil Eva Sámano de López Mateos, Morelia, Michoacán, México.
Insights
Inhaled steroids combined with salbutamol significantly improve asthma control in children. This approach offers better symptom management than short-acting beta-agonists alone for intermittent asthma.
Area of Science:
- Pediatric Allergy and Immunology
- Respiratory Medicine
- Pharmacology
Background:
- Intermittent childhood asthma often inadequately controlled by short-acting beta-agonists alone.
- Current treatment paradigms may not fully address disease progression.
Purpose of the Study:
- To evaluate the efficacy of salbutamol as a rescue medication when combined with other asthma therapies.
- To assess the impact of adding budesonide and/or montelukast to salbutamol for asthma control in children.
Main Methods:
- A study involving 50 children (1-14 years) with intermittent asthma.
- Treatment groups included salbutamol alone, salbutamol with budesonide, salbutamol with montelukast, and salbutamol with budesonide and montelukast.
- Asthma control was assessed after three months based on symptom resolution or significant symptom reduction.
Main Results:
- Inhaled corticosteroids (budesonide) plus salbutamol demonstrated superior asthma control compared to regimens without inhaled steroids (p < 0.05).
- The budesonide and salbutamol combination achieved total control in 44% and partial control in 56% of patients.
- The triple therapy (salbutamol, budesonide, montelukast) resulted in 47.1% total and 52.9% partial control.
Conclusions:
- Inhaled steroids are a key therapeutic option for enhancing control and potentially preventing the progression of intermittent asthma in children.
- Further research is needed to identify early markers for initiating inhaled corticosteroid therapy and determining optimal treatment duration.
Background:
Intermittent asthma in children is often treated only with short-action beta-agonists; however, most cases do not control totally the disease.
Objective:
To assess the effect of salbutamol, as rescue drug, associated with other drugs for controlling asthma.
Patients And Methods:
Fifty children, from 1 to 14 years old, with intermittent asthma, who were assisted at Out-Patient Consultation of Pediatric Allergy, Children Hospital Eva Samano de Lopez Mateos, from January to October, 2004, were selected. Treatment consisted of the following regimens: (1) salbutamol, (2) salbutamol and budesonide, (3) salbutamol and montelukast and (4) salbutamol, budesonide and montelukast. After three months of treatment asthma control degree was measured by disappearing of symptoms (total control) or decrease of symptoms in more than 70% a week (partial control).
Results:
A better control was observed in patients receiving budesonide (inhaled steroid) and salbutamol (p < 0.05), compared to those who were not treated with inhaled steroid. This regimen achieved in 44% the disappearing of symptoms (total control) and in 56% reduced the symptoms in more than 70% (partial control). Group receiving salbutamol, budesonide and montelukast reached a total and partial control in 47.1% and 52.9%, respectively.
Conclusions:
Inhaled steroids are a choice to better control and avoid the progression of intermittent asthma. The use of new progression markers of asthma should be evaluated, in order to determine which children may receive early inhaled steroids and how long.
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