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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Antigen Processing Pathways01:31

Antigen Processing Pathways

MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...

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Related Experiment Video

Updated: Jun 23, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

[Processing and pathogenicity of HCV core protein].

Kohji Moriishi1, Yoshio Mori, Yoshiharu Matsuura

  • 1Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, 3-1, Yamadaoka, Suita, Osaka 565-0871, Japan. kohji@biken.osaka-u.ac.jp

Uirusu
|April 21, 2009
PubMed
Summary

Hepatitis C virus (HCV) infection can lead to chronic liver disease, including cirrhosis and cancer. This review focuses on the HCV core protein

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A Protocol for Analyzing Hepatitis C Virus Replication
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10:23

Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis

Published on: April 17, 2017

Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors
16:49

Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors

Published on: July 16, 2012

Area of Science:

  • Virology
  • Hepatology
  • Oncology

Context:

  • Hepatitis C virus (HCV) causes chronic hepatitis, often leading to severe liver conditions like cirrhosis and hepatocellular carcinoma.
  • Chronic HCV infection is linked to other health issues, including cryoglobulinemia and type 2 diabetes mellitus.
  • Hepatocellular carcinoma development involves both chronic inflammation and the direct action of viral proteins.

Purpose:

  • To review the current understanding of Hepatitis C virus core protein processing.
  • To elucidate the pathogenic mechanisms of the HCV core protein.
  • To summarize the role of HCV core protein in disease progression.

Summary:

  • The Hepatitis C virus (HCV) core protein, a key component of the viral nucleocapsid, is implicated in the pathogenesis of HCV-related liver diseases.
  • HCV core protein contributes to disease progression by inducing oxidative stress and promoting cell growth.
  • Understanding the processing and pathogenicity of HCV core protein is crucial for developing targeted therapies.

Impact:

  • Provides a comprehensive overview of HCV core protein's role in disease.
  • Highlights the molecular mechanisms underlying HCV-induced liver damage and cancer.
  • Informs future research directions for antiviral strategies and hepatocellular carcinoma prevention.