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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
Published on: January 28, 2019
Australian Rotavirus Surveillance Program annual report, 2007/08
Carl D Kirkwood1, David Cannan, Karen Boniface
1National Rotavirus Reference Centre, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria. carl.kirkwood@mcri.edu.au
Communicable Diseases Intelligence Quarterly Report
|April 21, 2009
Summary
Rotavirus surveillance in Australia found G1 strains were most common after vaccine introduction. No unexpected changes in rotavirus serotypes were observed in the first year of the National Immunisation Program.
Area of Science:
- Virology
- Immunology
- Public Health
Background:
- The National Rotavirus Reference Centre conducts surveillance across Australia.
- Rotavirus causes acute gastroenteritis in children.
- The study period covers the first year post-introduction of rotavirus vaccine into the National Immunisation Program.
Purpose of the Study:
- To describe rotavirus strain types causing hospitalizations in children.
- To monitor rotavirus epidemiology following vaccine introduction.
Main Methods:
- Laboratory-based surveillance of 600 faecal samples nationwide.
- Utilized monoclonal antibody immunoassays and reverse transcription-polymerase chain reaction (RT-PCR).
Main Results:
- 419 samples confirmed positive for rotavirus.
- Dominant serotypes: G1 (52%), G2 (19.8%), G9 (12.2%), G3 (11%).
- Common P genotypes: P[8] with G1, G3, G9; P[4] with G2. Uncommon G8 and P[9] identified.
Conclusions:
- No unexpected changes in rotavirus serotype distribution observed in the first year of vaccine use.
- G1 remains the dominant serotype nationally.
- Surveillance data informs vaccine program effectiveness and future strategies.
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