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Updated: Jun 23, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Pluronic triblock copolymer systems and their interactions with Ibuprofen
Beth Foster1, Terence Cosgrove, Boualem Hammouda
1School of Chemistry, University of Bristol, Bristol, BS8 1TS, United Kingdom.
Temperature and ibuprofen concentration promote Pluronic micelle formation, influencing aggregation number, size, and solvent content. Hydrophobicity, drug quantity, and temperature significantly impact aggregation behavior.
Area of Science:
- Materials Science
- Physical Chemistry
- Polymer Science
Background:
- Pluronic block copolymers form micelles in aqueous solutions.
- Understanding micellar structure is crucial for drug delivery applications.
Purpose of the Study:
- Investigate structural changes in Pluronic micelles.
- Determine the effects of ibuprofen and temperature on micellization.
Main Methods:
- Small-angle neutron scattering (SANS).
- Pulsed-field gradient stimulated-echo nuclear magnetic resonance (PFG-SE-NMR).
Main Results:
- Increased temperature and ibuprofen concentration favor micellization.
- Aggregation number, fraction of polymer micellized, and core radius increased.
- Solvent volume fraction in the core decreased.
- Ibuprofen reduced the critical micellization temperature of Pluronic P104.
- High concentrations/temperatures indicated attractive micelle interactions or shape changes.
Conclusions:
- Pluronic micellar structure is sensitive to temperature and ibuprofen concentration.
- Hydrophobicity, drug amount, and temperature are key factors governing aggregation.
- Findings are relevant for optimizing Pluronic-based formulations.
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10:53Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
Published on: October 10, 2016
08:56Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
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