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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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PEPN1924, A Phase II Study of Trastuzumab Deruxtecan in Patients With Recurrent Human Epidermal Growth Factor Receptor 2+ Osteosarcoma: A Children's Oncology Group Pediatric Early-Phase Clinical Trial Network Study.

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An international framework for clinical translation of molecular classifiers in osteosarcoma.

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Sociodemographics and Attrition in Children With Osteosarcoma Enrolled in the AOST0331 Clinical Trial.

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Identification of CADM1 as an Immunotherapeutic Target and Evaluation of a Novel CADM1-Targeting Antibody-Drug Conjugate in Preclinical Osteosarcoma Models.

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Related Experiment Video

Updated: Jun 23, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Novel therapeutic agents for osteosarcoma.

Kathleen O'Day1, Richard Gorlick

  • 1Department of Pediatrics, Division of Pediatric Hematology/Oncology, The Children's Hospital at Montefiore, 3415 Bainbridge Avenue, Rosenthal 3rd floor, Bronx, NY 10467, USA. koday@montefiore.org

Expert Review of Anticancer Therapy
|April 21, 2009
PubMed
Summary
This summary is machine-generated.

New treatments are being developed for osteosarcoma, a common childhood bone cancer. These novel therapies aim to improve outcomes for patients who relapse after standard chemotherapy and surgery.

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Last Updated: Jun 23, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
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Published on: April 12, 2019

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
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Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

Area of Science:

  • Pediatric Oncology
  • Skeletal Oncology
  • Cancer Therapeutics

Background:

  • Osteosarcoma is the most frequent primary malignant bone tumor in children.
  • Current treatments including chemotherapy and surgery have limited efficacy, with high relapse rates (30% localized, 80% metastatic).
  • Patient survival has not improved in two decades, highlighting an urgent need for new therapeutic strategies.

Purpose of the Study:

  • To review novel therapeutic approaches for osteosarcoma.
  • To discuss emerging agents targeting signal-transduction pathways, tumor microenvironment, and immunomodulation.
  • To explore strategies for overcoming treatment resistance and novel drug delivery mechanisms.

Main Methods:

  • Review of current literature on novel osteosarcoma therapeutics.
  • Focus on agents in various stages of clinical development.
  • Discussion of preclinical and clinical findings related to new treatment modalities.

Main Results:

  • Several novel agents show promise in preclinical and early clinical studies.
  • Targeting specific signal-transduction pathways offers a new avenue for treatment.
  • Inhibitors of the tumor microenvironment and immunomodulatory agents are emerging as potential therapies.
  • Strategies to overcome drug resistance and novel delivery systems are under investigation.

Conclusions:

  • Novel therapeutic agents targeting signal-transduction pathways, the tumor microenvironment, and immune responses hold significant promise for improving osteosarcoma treatment.
  • Addressing treatment resistance and employing innovative drug delivery methods are crucial for enhancing therapeutic efficacy.
  • Further research and clinical trials are essential to translate these promising approaches into improved patient survival for osteosarcoma.