NADPH oxidase signaling and cardiac myocyte function
Related Experiment Video
Updated: Jun 23, 2026

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice
Published on: October 19, 2013
Ashwin Akki1, Min Zhang, Colin Murdoch
1Department of Cardiology, King's College London British Heart Foundation Centre of Excellence, The James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, UK.
Abstract:
The NADPH oxidase family of enzymes has emerged as a major source of reactive oxygen species (ROS) that is important in diverse cellular functions including anti-microbial defence, inflammation and redox signaling. Of the five known NADPH oxidase isoforms, several are expressed in cardiovascular cells where they are involved in physiological and pathological processes such as the regulation of vascular tone, cell growth, migration, proliferation, hypertrophy, apoptosis and matrix deposition. This article reviews current knowledge regarding the role of NADPH oxidases in cardiomyocyte function in health and disease.
Related Concept Videos
Nitric Oxide Signaling Pathway
Cardiac Action Potential
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
Pathophysiology of Cardiac Performance
Electrophysiology of Normal Cardiac Rhythm
Electron Transport Chain: Complex III and IV
Structure of Cardiac Muscles
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...

