Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 23, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

CD34 staining density predicts giant cell tumor clinical behavior.

Srinivas M Susarla1, Meredith August, Nathan Dewsnup

  • 1Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA 02114, USA. smsusarla@gmail.com

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
|April 21, 2009
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discussion: Principles and Techniques to Reduce the Incidence of Fistula: A Review of over 1000 Cleft Palate Repairs by a Single Surgeon.

Plastic and reconstructive surgery·2026
Same author

Reconstruction of Fistulas Following Cleft Palate Repair.

Oral and maxillofacial surgery clinics of North America·2026
Same author

Orthognathic Surgery for Cleft-Related Maxillomandibular Discrepancies.

Oral and maxillofacial surgery clinics of North America·2026
Same author

Management of Cleft Lip and Palate.

Oral and maxillofacial surgery clinics of North America·2026
Same author

Discussion: Demystifying Maxillomandibular Fibrous Dysplasia and Its Impact on Dental Development.

Plastic and reconstructive surgery·2026
Same author

Value of Personal Engagement Versus Delegation in Surgical Practice.

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons·2025

High CD34 staining density in giant cell tumors predicts aggressive behavior. This molecular marker can help differentiate between aggressive and nonaggressive giant cell lesions.

Area of Science:

  • Oral and Maxillofacial Pathology
  • Oncology
  • Immunohistochemistry

Background:

  • Giant cell tumors (GCTs) are neoplasms that can exhibit variable clinical behavior.
  • Accurate prediction of GCT clinical behavior is crucial for appropriate patient management.
  • Identifying reliable molecular markers for GCTs is an ongoing area of research.

Purpose of the Study:

  • To investigate the utility of CD34 staining density as a predictive marker for the clinical behavior of giant cell tumors.
  • To evaluate the association between CD34 expression levels and the aggressiveness of giant cell lesions in the jaws.

Main Methods:

  • Retrospective analysis of 32 patients with giant cell lesions of the jaws over a 15-year period.
  • Quantification of mean CD34 staining density using immunohistochemistry.

More Related Videos

Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma
09:06

Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma

Published on: November 11, 2021

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Related Experiment Videos

Last Updated: Jun 23, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma
09:06

Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma

Published on: November 11, 2021

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

  • Bivariate analyses and logistic regression to assess the association between CD34 density and clinical behavior (aggressive vs. nonaggressive).

    • Main Results:

    • Mean CD34 staining density was significantly higher in aggressive lesions (5.1%) compared to nonaggressive lesions (2.2%) (P = .02).
    • A CD34 staining threshold of ≥2.5% demonstrated high sensitivity (0.77) and specificity (0.83) for predicting aggressive behavior.
    • CD34 levels >2.5% were strongly associated with aggressive giant cell tumors (odds ratio: 16.7, P = .04).

    Conclusions:

    • CD34 staining density serves as a valuable molecular marker for predicting the clinical behavior of giant cell tumors.
    • Elevated CD34 expression (≥2.5%) is indicative of aggressive giant cell lesions in the jaw.
    • Immunohistochemical analysis of CD34 can aid in differentiating aggressive from nonaggressive giant cell tumors.