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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Diffuse microstructural abnormalities of normal-appearing white matter in late life depression: a diffusion tensor

Joshua S Shimony1, Yvette I Sheline, Gina D'Angelo

  • 1Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.

Biological Psychiatry
|April 21, 2009
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Late-life depression (LLD) shows widespread white matter abnormalities in normal-appearing white matter, particularly in prefrontal regions. Cognitive processing speed strongly correlated with these diffusion tensor imaging (DTI) changes.

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Area of Science:

  • Neuroimaging
  • Geriatric Psychiatry
  • Neuroscience

Background:

  • Recent studies link late-life depression (LLD) to white matter abnormalities, including white matter hyperintensities (WMH).
  • Previous research has not investigated white matter integrity in normal-appearing white matter (NAWM) in LLD.

Purpose of the Study:

  • To examine white matter integrity in NAWM in individuals with LLD.
  • To correlate diffusion tensor imaging (DTI) findings with cognitive function in LLD.

Main Methods:

  • T1-weighted, T2-weighted, and diffusion tensor imaging (DTI) were performed on 73 individuals with LLD and 23 matched controls.
  • Structural images were segmented; DTI parameters were calculated in white matter regions of interest, excluding WMH.

Main Results:

  • Widespread abnormalities in DTI parameters were observed in the LLD group compared to controls, especially in prefrontal regions.
  • Cognitive processing speed showed the strongest correlation with DTI abnormalities.

Conclusions:

  • The findings suggest significant white matter changes in NAWM in LLD.
  • Further research is needed to explore the potential reversibility and prognosis associated with these white matter abnormalities in LLD.