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Preparation and Analysis of Histological Slides of Rat and Mouse Eyeballs to Evaluate the Retina
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Naturally occurring animal models with outer retina phenotypes.

Wolfgang Baehr1, Jeanne M Frederick

  • 1John A. Moran Eye Center, Department of Ophthalmology and Visual Sciences, 65 Mario Capecchi Dr., Salt Lake City, UT 84132, USA. wbaehr@hsc.utah.edu

Vision Research
|April 21, 2009
PubMed
Summary

Animal models are crucial for studying human retinal degenerations like retinitis pigmentosa. Research on these models advances understanding of disease causes and potential gene therapies.

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Area of Science:

  • Ophthalmology
  • Genetics
  • Animal Models

Background:

  • Animal models are vital for investigating human retinal degenerations such as retinitis pigmentosa, Leber congenital amaurosis, cone dystrophies, and macular degeneration.
  • Significant advancements have been made in identifying genetic defects and disease mechanisms.

Purpose of the Study:

  • To review the history, phenotypes, and gene defects of animal models exhibiting outer retinal degeneration.

Main Methods:

  • Review of naturally occurring and laboratory-generated animal models.
  • Focus on murine and canine models with photoreceptor and retinal pigment epithelium degeneration.

Main Results:

  • Identification of key animal models for studying retinal degeneration.

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  • Elucidation of gene defects and disease mechanisms in these models.

    • Conclusions:

    • Animal models, particularly murine and canine mutants, are instrumental in understanding retinal degeneration.
    • This research supports the development of translational research and gene-based therapies for inherited retinal diseases.