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High-molecular weight adiponectin is associated with coronary artery angiographic findings in Asian Indians
Taiba Zornitzki1, Naama Reshef, Oded Ayzenberg
1Metabolic Unit and Department of Medicine, Kaplan Medical Center, Rehovot and the Hebrew University Hadassah Medical School, Rehovot, Israel.
Insights
Asian Indians (AIs) exhibit more severe coronary artery disease (CAD) than whites. In AI men, adiponectin levels correlate with CAD severity, suggesting a potential role in accelerated disease progression.
Area of Science:
- Cardiology
- Endocrinology
- Genetics
Background:
- Asian Indians (AIs) present with a higher prevalence and more aggressive coronary artery disease (CAD).
- Hypoadiponectinemia is a potential factor in accelerated CAD among AIs.
- This study investigates adiponectin's role in CAD severity in AIs versus whites.
Purpose of the Study:
- To compare the extent and severity of angiographic findings in CAD patients of Asian Indian and white ethnicity.
- To explore the relationship between adiponectin (total and high-molecular weight [HMW]) and CAD severity in these groups.
Main Methods:
- Comparison of angiographic findings (modified Gensini index scores 1 and 2) between age- and sex-matched AI (n=29) and white (n=30) CAD patients.
- Measurement of total and HMW adiponectin levels.
- Correlation analysis between adiponectin levels and Gensini scores.
Main Results:
- AI patients demonstrated significantly higher Gensini index scores (indicating more severe CAD) compared to white patients (P < .05).
- Adiponectin levels were similar between groups.
- In AI men, both total and HMW adiponectin showed a positive association with CAD severity scores (Gensini index scores 1 and 2).
- No significant association was found in white men.
Conclusions:
- Asian Indians experience more severe coronary artery disease compared to whites.
- In AI men with CAD, adiponectin levels are associated with the severity of angiographic findings, suggesting a potential mechanistic link.
Abstract:
Asian Indians (AIs) have a higher prevalence and a more aggressive form of coronary artery disease (CAD), and it has been suggested that hypoadiponectinemia may have a role in this accelerated CAD. The present study was undertaken to determine the extent and severity of angiographic findings in 2 groups of CAD patients matched for age and sex, AIs (n = 29) vs whites (n = 30), and to elucidate the potential relationship between adiponectin (total and high-molecular weight [HMW] form) and the severity and extent of coronary angiographic findings in both groups. Angiographic findings were assessed using the modified Gensini index; and 2 scores, scores 1 and 2, were used to assess the severity and extent. Both Gensini index scores 1 and 2 were higher in the AI group compared with the white group (144.4 +/- 87.1 vs 93.5 +/- 56.3 and 127.2 +/- 86.5 vs 80.1 +/- 39.3, respectively; P < .05). Adiponectin levels were similar in both groups. Total adiponectin and HMW adiponectin were positively associated with Gensini index score 1 (r = 0.62, P = .004 and r = 0.64, P = .003) and score 2 (r = 0.51, P = .021 and r = 0.54, P = .013), respectively, in AI men, whereas there was no significant association in white men. Thus, AIs had more severe CAD compared with whites; and in AI men with CAD, total adiponectin and HMW adiponectin were associated with the severity of angiographic scores.
