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Related Concept Videos

Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Urinary Tract Infection IV: Nursing Management01:17

Urinary Tract Infection IV: Nursing Management

In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs like...

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Related Experiment Video

Updated: Jun 23, 2026

A Catheter-Related Candida albicans Infection Model in Mouse
03:24

A Catheter-Related Candida albicans Infection Model in Mouse

Published on: March 22, 2024

Candida in the ICU.

Rabih O Darouiche1

  • 1Michael E. Debakey Veterans Affairs Medical Center, Infectious Disease Section (Room 4B-370), Houston, TX 77030, USA. rdarouiche@aol.com

Clinics in Chest Medicine
|April 21, 2009
PubMed
Summary
This summary is machine-generated.

Invasive Candida infections pose a significant threat to critically ill patients. Early antifungal treatment is crucial, but guidelines for suspected, undocumented cases require further development.

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07:42

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract

Published on: July 1, 2020

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Mycology

Background:

  • Invasive Candida infections are increasingly prevalent in critically ill patients.
  • These infections lead to severe illness, mortality, and high healthcare costs.
  • Timely diagnosis and antifungal therapy are essential for improving patient outcomes.

Purpose of the Study:

  • To address the lack of clear guidelines for managing suspected but unconfirmed invasive Candida infections in critically ill patients.
  • To highlight the need for better identification of patient groups who may benefit from empiric antifungal therapy.
  • To explore novel strategies for managing Candida-infected medical devices.

Main Methods:

  • Literature review on invasive Candida infections in critically ill populations.
  • Analysis of current treatment strategies for documented and suspected cases.
  • Discussion of challenges in diagnosing and managing these infections.

Main Results:

  • Established treatment protocols exist for documented deep-seated Candida infections in nonneutropenic patients.
  • Guidelines for suspected but undocumented invasive Candida infections in the critically ill are not well-defined.
  • The study identifies a need for further research in specific areas.

Conclusions:

  • Further research is needed to identify critically ill patients who would benefit from empiric antifungal therapy for suspected invasive Candida infections.
  • Novel approaches for salvaging Candida-infected devices warrant investigation.
  • Improved diagnostic and management strategies are crucial for this vulnerable patient population.