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Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
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Noninvasive pulmonary Aspergillus infections

Brent P Riscili1, Karen L Wood

  • 1Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The Ohio State University Medical Center, Davis Heart and Lung Research Institute, Columbus, OH 43210, USA.

Clinics in Chest Medicine
|April 21, 2009
PubMed

Insights

This review covers noninvasive pulmonary Aspergillus infections like ABPA, aspergilloma, and CPA. It details their clinical presentation, diagnosis, pathogenesis, and treatment, focusing on host immune factors.

Area of Science:

  • Pulmonology
  • Mycology
  • Infectious Diseases

Background:

  • Aspergillus species cause various pulmonary diseases, influenced by host lung and immune status.
  • Noninvasive forms include Allergic Bronchopulmonary Aspergillosis (ABPA), Aspergilloma, and Chronic Pulmonary Aspergillosis (CPA).

Purpose of the Study:

  • To review the clinical presentation, diagnosis, pathogenesis, and treatment of noninvasive pulmonary Aspergillus infections.
  • To differentiate between ABPA, Aspergilloma, and CPA based on host factors and clinical characteristics.

Main Methods:

  • Literature review of clinical presentations.
  • Review of diagnostic approaches.
  • Analysis of pathogenesis and treatment strategies for noninvasive Aspergillus infections.

Main Results:

  • ABPA results from a hypersensitivity reaction to Aspergillus, often in asthma or cystic fibrosis patients.
  • Aspergillomas are fungal balls in pre-existing lung cavities, commonly post-tuberculosis.
  • CPA, or semi-invasive aspergillosis, typically affects individuals with underlying lung disease or mild immunosuppression.

Conclusions:

  • Understanding host factors is crucial for differentiating and managing noninvasive pulmonary Aspergillus infections.
  • Accurate diagnosis and tailored treatment are essential for improving outcomes in patients with ABPA, Aspergilloma, and CPA.

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