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Spontaneous electrical waveforms in aging guinea pig prostates.

Anupa Dey1, Dan-Thanh T Nguyen, Richard J Lang

  • 1Prostate Research Co-operative, Victorian College of Pharmacy, Monash University, Parkville, Victoria, Australia.

The Journal of Urology
|April 21, 2009
PubMed
Summary

Spike activity in the aging guinea pig prostate increases with age, potentially explaining increased prostatic tone. Nifedipine blocks spike activity, indicating L-type channel involvement, but not spontaneous transient depolarizations.

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Area of Science:

  • Urology
  • Physiology
  • Pharmacology

Background:

  • Aging is associated with increased prostatic tone.
  • Spontaneous electrical activity in the prostate is not well understood.

Purpose of the Study:

  • To characterize spontaneous electrical activity in the aging guinea pig prostate.
  • To investigate the role of L-type calcium channels in prostatic electrical activity.

Main Methods:

  • Conventional single microelectrode recordings of membrane potential.
  • Analysis of spontaneous waveforms: spikes, slow waves, and spontaneous transient depolarizations.
  • Pharmacological assessment using nifedipine.

Main Results:

  • Three spontaneous waveforms were identified: spikes, slow waves, and spontaneous transient depolarizations.

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  • Spike activity increased with age and was significantly affected by nifedipine, suggesting L-type channel involvement.
  • Spontaneous transient depolarizations were not affected by nifedipine, indicating alternative generation mechanisms.

    • Conclusions:

    • Increased spike activity with aging may contribute to increased prostatic tone.
    • Nifedipine's effect on spike activity and slow waves implicates L-type channels.
    • Spontaneous transient depolarizations are generated independently of L-type calcium channels.