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Valorization of the Red Seaweed Gracilaria gracilis Through a Biorefinery Approach

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Screening for bioactive compounds from algae.

M Plaza¹, S Santoyo, L Jaime

¹Departamento de Caracterización de Alimentos, Instituto de Fermentaciones Industriales (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.

Journal of Pharmaceutical and Biomedical Analysis

|April 21, 2009

Summary

Researchers developed a new method to screen for natural functional compounds from algae and microalgae. This approach identified potent antioxidant and antimicrobial activities, correlating them with specific chemical compositions.

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Area of Science:

Natural Product Chemistry
Marine Biotechnology
Analytical Chemistry

Background:

The search for novel natural functional compounds is crucial for various industries.
Unexplored natural sources like algae and microalgae offer a promising reservoir of bioactive molecules.
Environmentally friendly extraction and advanced analytical techniques are needed for efficient screening.

Purpose of the Study:

To present a comprehensive methodology for screening novel natural functional compounds.
To utilize unexplored natural sources (algae, microalgae) with green extraction techniques.
To correlate functional activities (antioxidant, antimicrobial) with chemical composition.

Main Methods:

Development of a new screening strategy using algae and microalgae.
Application of environmentally clean extraction techniques and advanced analytical tools (GC-MS, HPLC-DAD).
Estimation of functional activities and chemical characterization of extracts.

Main Results:

Screening of *Himanthalia elongata* and *Synechocystis sp.* yielded active extracts.
Extracts demonstrated significant antioxidant and antimicrobial activities.
Identified antimicrobial compounds include fatty acids (palmitic, palmitoleic, oleic) and volatile compounds (phytol, fucosterol, neophytadiene).

Conclusions:

The developed methodology effectively screens for bioactive compounds from marine sources.
Ethanol was identified as the optimal solvent for extracting these functional compounds.
Algae and microalgae are valuable sources of natural compounds with antioxidant and antimicrobial properties.