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Related Experiment Video

Updated: Jun 23, 2026

Transcriptional Analysis by Nascent RNA FISH of In Vivo Trophoblast Giant Cells or In Vitro Short-term Cultures of Ectoplacental Cone Explants
08:26

Transcriptional Analysis by Nascent RNA FISH of In Vivo Trophoblast Giant Cells or In Vitro Short-term Cultures of Ectoplacental Cone Explants

Published on: August 31, 2016

Recognising gestational trophoblastic disease.

Dalya Alhamdan1, Tommaso Bignardi, George Condous

  • 1Acute Gynaecology, Early Pregnancy and Advanced Endosurgery Unit, Nepean Centre for Perinatal Care, Nepean Clinical School, University of Sydney, Sydney, Australia. doctord972@yahoo.com

Best Practice & Research. Clinical Obstetrics & Gynaecology
|April 21, 2009
PubMed
Summary
This summary is machine-generated.

Transvaginal ultrasound (TVS) aids in diagnosing molar pregnancies but has limitations, especially in early stages. Histological confirmation remains the gold standard for gestational trophoblastic disease (GTD).

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Last Updated: Jun 23, 2026

Transcriptional Analysis by Nascent RNA FISH of In Vivo Trophoblast Giant Cells or In Vitro Short-term Cultures of Ectoplacental Cone Explants
08:26

Transcriptional Analysis by Nascent RNA FISH of In Vivo Trophoblast Giant Cells or In Vitro Short-term Cultures of Ectoplacental Cone Explants

Published on: August 31, 2016

Area of Science:

  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Diagnostic Imaging

Background:

  • Gestational trophoblastic disease (GTD) encompasses placental tumors, with hydatidiform mole (HM) being most common.
  • Complete hydatidiform mole (CHM) carries a higher risk of persistent disease than partial hydatidiform mole (PHM).
  • Early recognition of molar pregnancy via transvaginal ultrasound (TVS) can improve surgical planning and identify at-risk patients.

Purpose of the Study:

  • To critically evaluate the role and limitations of TVS in the pre-surgical diagnosis of GTD.
  • To assess the accuracy of TVS in identifying different types of molar pregnancies.
  • To highlight the importance of histological confirmation in GTD diagnosis.

Main Methods:

  • Review of current literature on TVS performance in molar pregnancy diagnosis.
  • Analysis of ultrasound sensitivity and specificity for CHM and PHM.
  • Discussion of factors affecting TVS diagnostic accuracy, including early-stage hydropic changes.

Main Results:

  • TVS sensitivity for HM diagnosis ranges from 50-86%, with CHM diagnosed in ~80% of cases.
  • Ultrasound diagnosis of PHM is less accurate, with nearly 70% missed.
  • Minimal hydropic changes in early pregnancy can lead to missed diagnoses by TVS.

Conclusions:

  • While TVS is valuable for pre-surgical recognition of molar pregnancies, its diagnostic performance is suboptimal, particularly for PHM.
  • Correlation with human chorionic gonadotropin levels may enhance pre-surgical diagnosis.
  • Histological confirmation post-curettage remains the definitive gold standard for GTD diagnosis.