Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HLA-DRB nucleotide sequences arranged in polymorphic groups.

A A Ansari1

  • 1Johns Hopkins Asthma & Allergy Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

The Indian Journal of Medical Research
|June 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative evaluation of saturated and 10% potassium iodide in reducing silver diamine fluoride staining under RMGIC restorations in primary teeth.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2026
Same author

Early treatment of SIV+ macaques with an α<sub>4</sub>β<sub>7</sub> mAb alters virus distribution and preserves CD4<sup>+</sup> T cells in later stages of infection.

Mucosal immunology·2018
Same author

The loss of CCR6<sup>+</sup> and CD161<sup>+</sup> CD4<sup>+</sup> T-cell homeostasis contributes to disease progression in SIV-infected rhesus macaques.

Mucosal immunology·2017
Same author

Endogenous interleukin-22 protects against inflammatory bowel disease but not autoimmune cholangitis in dominant negative form of transforming growth factor beta receptor type II mice.

Clinical and experimental immunology·2016
Same author

Immunological potential of cytotoxic T lymphocyte antigen 4 immunoglobulin in murine autoimmune cholangitis.

Clinical and experimental immunology·2015
Same author

Successful immunotherapy of autoimmune cholangitis by adoptive transfer of forkhead box protein 3(+) regulatory T cells.

Clinical and experimental immunology·2014

This review presents human leukocyte antigen (HLA)-DR B gene nucleotide sequences for designing sequence-specific oligonucleotide (SSO) probes. It also illustrates the relationships among different HLA-DR alleles for improved DNA typing.

Area of Science:

  • Immunogenetics
  • Molecular Biology
  • Genomics

Background:

  • Human Leukocyte Antigen (HLA) genes are crucial for immune response and transplantation.
  • Accurate DNA typing of HLA alleles is essential for clinical diagnostics and research.
  • Sequence-specific oligonucleotide (SSO) probes offer a reliable method for HLA typing.

Purpose of the Study:

  • To compile and present nucleotide sequence information for HLA-DR B genes.
  • To facilitate the design of sequence-specific oligonucleotide (SSO) probes for HLA-DR B DNA typing.
  • To elucidate the relationships between various HLA-DR alleles.

Main Methods:

  • Compilation of available nucleotide sequence data for HLA-DR B genes.
  • Analysis of sequence variations to identify regions suitable for SSO probe design.

Related Experiment Videos

  • Comparative analysis of HLA-DR alleles to illustrate genetic relationships.

    • Main Results:

    • A formatted presentation of HLA-DR B gene nucleotide sequences.
    • Identification of key sequence features for designing effective SSO probes.
    • A visual representation of the relationships among different HLA-DR alleles.

    Conclusions:

    • The provided sequence information is valuable for developing precise SSO-based DNA typing strategies for HLA-DR B genes.
    • Understanding allele relationships aids in the interpretation of DNA typing results.
    • This resource supports advancements in HLA-DR B genotyping and related fields.